Live mpox (monkeypox) statistics for South Africa, updated automatically from World Health Organization surveillance data.
First case 3 Jul 2022 · latest WHO report 15 Sep 2026 · updates automatically
As of 27 September 2026, South Africa has reported 64 confirmed mpox (monkeypox) cases and 3 deaths to the World Health Organization, with the first confirmed case recorded on 3 July 2022. That is the 72nd highest total worldwide and the 23rd in Africa. The rate is 1.0 cases per million people (below the world average of 23.6). 13 new cases were reported in the last 90 days, up from 3 in the previous 90 days (+333%).
Total confirmed cases: South Africa
Cumulative confirmed cases by report date
South Africa: 64 confirmed cases.
New confirmed cases: South Africa
By month of report to WHO
South Africa: 13 cases in the last 90 days.
Latest reports: South Africa
Most recent submissions to WHO
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Mpox in South Africa: frequently asked questions
How many mpox cases are there in South Africa?
South Africa has reported 64 laboratory-confirmed mpox (monkeypox) cases to WHO as of 27 September 2026, the 72nd highest total of 145 countries with cases.
How many people have died from mpox in South Africa?
3 mpox deaths have been confirmed in South Africa, a case fatality rate of 4.69%. Worldwide the rate is about 0.28%.
Are mpox cases rising in South Africa?
13 new cases were reported in the last 90 days, up from 3 in the previous 90 days (+333%). The latest report to WHO is dated 15 September 2026.
Has clade Ib mpox been found in South Africa?
Clade Ib has not been reported for South Africa in WHO situation reports so far. Cases there have been clade II or clade Ia. The worldwide list of clade Ib countries is on the main tracker page.
When was the first mpox case in South Africa?
The first confirmed case in WHO data for South Africa was recorded on 3 July 2022.
How does South Africa compare with other countries?
South Africa has 1.0 confirmed cases per million people, against a world average of 23.6. It ranks 23rd in Africa by total cases.
How can I protect myself from mpox?
Avoid close, skin-to-skin contact with people who have a rash that looks like mpox, do not share bedding, towels or utensils with someone who is sick, and wash hands often. Vaccination with MVA-BN is recommended for people at higher risk; check with local health services in South Africa for availability.